A robust, sensitive, and reliable multi-residue LC-MS/MS method workflow solution that uses the Thermo Scientific TSQ Altis triple quadrupole mass spectrometer provides analysis and quantitation of more than 160 veterinary drugs with the Thermo Scientific VetDrugs Explorer Collection solution in salmon (fillet), bovine muscle, and milk. The complete instrument and data processing method including SRM settings is included with the VetDrugs Explorer Collection start-to-finish workflow solution. In 17 minutes, the target veterinary drugs were detected and quantified in food matrices.
Veterinary drugs are pharmacologically active compounds that can result in non-desirable drug residues in the food chain. Animals with high amounts of these drugs can cause harm in humans or can render the use of antibiotics useless due to the counter effects of the drugs. The quantification of over 200 multi-class veterinary drugs from different meat products usually involves time consuming extraction methods with either SPE or LLE. We describe a robust method, utilizing a single LC-MS/MS run to quantitate over 200 veterinary drugs in a variety of matrices.
Sulfonamides are used widely as anti-inflammatory medications for humans and livestock, and have recently become compounds of interest to regulatory agencies worldwide. Triple stage quadrupole LC-MS systems are often used for highly sensitive quantitative analyses of environmental pollutants. Performance of the LC-MS and sample pre-treatment are 2 critical factors that determine efficiency and accuracy in detection of low concentrations of pollutants in environmental samples. We describe a method for the quantitative analysis of sulfonamide antibiotics using EQuan.
This application shows the advantages of using the Thermo Scientific™ Hypersil GOLD aQ VANQUISH™ 1.9 µm column and Thermo Scientific™ Vanquish™ UHPLC system, for the fast analysis of sulfur-containing drugs. The built-in method scaling of the Chromeleon software and high pressure capabilities of the Hypersil GOLD VANQUISH columns, that allow operation at higher flow rates,enable the development of rapid analytical methods whilst maintaining high performance.
Antibiotics are widely used to treat diseased animals, prevent diseases and promote growth. However, inappropriate or excessive usage of antibiotics can result in antibiotic residues being found found in food and food products of animal origin. In here, a multi-residue, confirmatory method for the quantitative determination of antibiotics in chicken meat is described using the Thermo Scientific Transcend TLX system coupled to an LC-MS/MS. With online sample cleanup and high sample throughput, this approach addresses the demand for a fast and cost-effective multi-analyte method.
