This application shows the advantages of using the Thermo Scientific™ Hypersil GOLD aQ VANQUISH™ 1.9 µm column and Thermo Scientific™ Vanquish™ UHPLC system, for the fast analysis of sulfur-containing drugs. The built-in method scaling of the Chromeleon software and high pressure capabilities of the Hypersil GOLD VANQUISH columns, that allow operation at higher flow rates,enable the development of rapid analytical methods whilst maintaining high performance.
Antibiotics are widely used to treat diseased animals, prevent diseases and promote growth. However, inappropriate or excessive usage of antibiotics can result in antibiotic residues being found found in food and food products of animal origin. In here, a multi-residue, confirmatory method for the quantitative determination of antibiotics in chicken meat is described using the Thermo Scientific Transcend TLX system coupled to an LC-MS/MS. With online sample cleanup and high sample throughput, this approach addresses the demand for a fast and cost-effective multi-analyte method.
Forty-four multi-class veterinary drugs of known concentrations were employed to demonstrate how the use of a generic variable data-independent acquisition (vDIA) method with wide MS/MS precursor isolation windows achieves sensitivity and selectivity comparable to data-dependent MS2 acquisition (using narrow isolation windows) in quantitative and qualitative small molecule applications. In addition, a full record of MS and MS/MS data for the measured sample fit for non-targeted and unknown screening purposes is delivered. vDIA is not available in the United States of America
The use of LC-MS/MS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk.
To describe a new method for veterinary drug analysis, showing how the variable data-independent acquisition (vDIA) workflow achieves high sensitivity and selectivity, providing a complete high-quality data record of the measured sample. Quantitative analysis of the acquired data in combination with non-targeted and unknown screening is shown. vDIA is not available in the United States of America
