We present a liquid chromatography – high-resolution, accurate-mass (LC-HRAM) methodology using Orbitrap technology as a sensitive, accurate, and reliable quantitative alternative to the use of triple quadrupole mass spectrometers while simultaneously determining unknown perfluorinated compounds in the same drinking water extracts. Based on the EPA method flexibility rule, QA/QC requirements and guidance within EPA Method 537, HRAM Orbitrap technology should be permissible for potential compliance monitoring if PFASs become regulated compounds in US drinking waters.
The separation of perfluoro-octanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in tap water was performed on a Thermo Scientific Acclaim PolarAdvantage II (PA2) HPLC column, with on-line sample concentration and suppressed conductivity detection. Chromatogram A is Sunnyvale tap water spiked with PFOA and PFOS and chromatogram B is a control.
