The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ TSQ Quantis™ Plus mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ Orbitrap Exploris™ mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
HPLC-MS/MS separation for the tobacco alkaloids nicotine, nornicotine, cotinine, norcotinine, trans-3’-hydroxycotinine, and anabasine.
Since the introduction of electronic cigarettes in 2007, their use has increased worldwide as an alternative to conventional tobacco cigarettes. Electronic cigarette liquids (e-liquids) can contain nicotine, a highly addictive drug that is toxic in high doses, may increase heart attack risk, and can affect reproductive health. Studies have shown that nicotine can also interfere with memory and attention processing especially in adolescents.
Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.
