To develop a fast, robust UHPLC method for mebendazole and related impurities using an automated method development workflow.
To demonstrate how custom injection programs affect chromatographic parameters such as asymmetry, resolution, and efficiency of a selected EP method.
The current application demonstrates the straightforward transfer of an EP monograph HPLC method from a Waters Acquity UPLC system to a Thermo Scientific Vanquish Horizon UHPLC system. During the transfer flexible thermostatting options provided by the Vanquish platform help to mimic the actual conditions at the original system. Substantial time and solvent savings are obtainable by speeding up the conventional HPLC method to UHPLC conditions without sacrificing chromatographic performance.
A robust, sensitive, and reliable multi-residue LC-MS/MS method workflow solution that uses the Thermo Scientific TSQ Altis triple quadrupole mass spectrometer provides analysis and quantitation of more than 160 veterinary drugs with the Thermo Scientific VetDrugs Explorer Collection solution in salmon (fillet), bovine muscle, and milk. The complete instrument and data processing method including SRM settings is included with the VetDrugs Explorer Collection start-to-finish workflow solution. In 17 minutes, the target veterinary drugs were detected and quantified in food matrices.
