Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.
The Thermo Scientific Dionex Ultimate 3000 HPLC system was applied for the impurity analysis of loratadine in formulation. The Thermo Scientific Hypersil GOLD HPLC column performed the separation of loratadine and its impurities in 55 minutes with UV detection at 254 nm.