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Assay and related substances analysis of Cefotaxime sodium using a C18 HPLC column as per JP XVI and KP X monograph methods
Description
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the assay and related substances analysis of Cefotaxime Sodium. The analysis was performed on a Thermo Scientific Syncronis aQ HPLC column using the method described in the JP XVI/KP X. The results obtained for resolution and symmetry factor met the criteria stated in the JP/KP. The results obtained for resolution between the peaks due to desacetyl Cefotaxime and Cefotaxime was 32.8(JP/KP criteria of minimum 20.0) and symmetry factor for cefotaxime was 1.0 (JP/KP criteria of maximum 2).| Market: | Pharma |
| Keywords: | Cefotaxime, HPLC, Syncronis aQ, UV detection, JP XVI monograph, KP X monograph, beta-lactam antibiotic |
| Matrix: | N/A |
| Author: | Krishnarao Dara |
| Affiliation: | APAC CoE Lab, Ahmedabad, India |
For Research Use Only. Not for use in diagnostic procedures.
