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EP 8.0 monograph: impurity determination of trimethoprim (for impurities E, D, G, B, J and F) using a C18 HPLC column
Description
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of trimethoprim and its impurities (E, D, G, B, J and F). The separation was performed on a Thermo Scientific Hypersil Gold HPLC column using the method described in the EP 8.0 monograph. The results obtained for resolution and tailing factor exceeded the criteria stated in the EP. Resolution between impurity E and trimethoprim was 7.7 (EP criteria of not less than 2.5) and tailing factor for trimethoprim was 1.1 (EP criteria not more than 2.0).| Market: | Pharma |
| Keywords: | HPLC, Hypersil GOLD, UV detection, EP 8.0 monograph, Trimethoprim |
| Matrix: | N/A |
| Author: | Manish singh |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
