AN263: Sensitive and Fast Determination of Endothall in Saline Water Sample by IC-MS/MS

Instrument Type: ICMS

Endothall, a widely used herbicide for both terrestrial and aquatic weeds, is a regulated contaminant for drinking water having a California Public Health Goal of 580 ppb. Here trace-level endothall in a saline water sample was determined directly without labor-intensive sample preparation by IC-MS-MS. The MS/MS instrument was operated in selected reaction monitoring (SRM) mode, requiring minimal sample cleanup and ensuring highly sensitive (low ppb) and selective quantitation. Isotope labeled glutaric acid (glutaric acid–d6) was used as an internal standard to ensure quantitation accuracy.