UHPLC Method Development for Simultanous Determination of Antihypertensive Combination Agents

Instrument Type: UHPLC

The current trend in antihypertensiion therapy is the medication with several antihypertension agents in a single pill. Here eluent switching capabilities of the Thermo Scientific Vanquish Binary pump H are applied to develop a UHPLC method for simultanous determination of antihypertensive combination agents on a Thermo Scientific Accucore Vanquish C18+ column by scouting different eluent combinations.

Fast and Easy HPLC Method Development: Application of an Automated Method Scouting System for the Separation of Hypertension Drug Formulation

Instrument Type: UHPLC

The Automated Method Scouting Solution with Chromeleon CDS 7.2 allows an efficient screening of methods. The user-friendly solution requires no manual interaction and runs unattended. By applying the Custom Injection Variables the needed instrument methods for altering chromatographic conditions is decreased to a minimum. Easy generation of a method scouting sequence is provided by a dedicated eWorkflow which already contains Custom Injection Variables and related instrument methods. Predefined test case criteria and queries help to extract the most promising methods.