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AN1022:Determination of Voriconazole Related Compound F in Voriconazole Using IC

Instrument Type: IC

The USP method, which specifies the Thermo Scientific Dionex OmniPac PAX-100 Analytical Column (4 × 250 mm) with manually prepared eluent and chemically suppressed conductivity detection, was evaluated for the determination of voriconazole related compound F with a threshold amount of no more than 5 μg/mL (0.1%) in a 5 mg/mL solution of voriconazole, which is the final concentration amount for intravenous (IV) administration. The method was found to successfully determine voriconazole related compound F as required by the proposed USP method.