Determination of Sulfate and Sulfamate in Topiramate Using a Compact Reagent-Free Ion Chromatography System

Instrument Type: IC

Determination of sulfamate and sulfate are used to monitor and confirm topiramate degradation. In application note 238 we demonstrate the use of a Reagent-Free Ion Chromatography (IC) system with a Thermo Scientific Dionex IonPac AS11 column and suppressed conductivity detection for the determination of sulfamate and sulfate in topiramate. This record shows that the method can be run using a new compact IC system: the Thermo Scientific Dionex Integrion system.

AN238: Determination of Sulfate and Sulfamate in Topiramate Using a Reagent-Free Ion Chromatography System

Instrument Type: IC

In this application note (AN), we demonstrate the use of a Reagent-Free™ Ion Chromatography (IC) system with the IonPac® AS11 column and suppressed conductivity detection for the determination of sulfamate and sulfate in topiramate. The IonPac AS11 column has been successfully used in the pharmaceutical industry and is currently specified in several USP methods, including an assay for citric acid/citrate and phosphate in different pharmaceutical formulations, phosphite in etidronate disodium, and free sulfate in enoxaparin sodium injection. The IonPac AS11 column consists of a 13 μm micropo...