Quantitation of THC and THC Metabolites in Blood Using SOLAµ SPE Plates and the TSQ Quantiva Triple Quadrupole Mass Spectrometer for Forensic Analysis

Instrument Type: LCMSMS

Cannabis is the most frequently abused drug and THC the major psychoactive constituent. THC is primarily metabolized to THC-OH, which has equipotent psychoactivity and is further metabolized to nonpsychoactive THC-COOH. Second-phase metabolites, are also present in blood and can be used as markers to determine recency of intake while improving interpretation of analytical results. LC-MS analytical methods are widely used for analysis of THC and metabolites. LC-MS methods do not require sample derivatization, thus yielding savings over typical GC-MS procedures. For forensic use only.