AN259: Determination of N-Methylpyrrolidine in Cefepime with Nonsuppressed Conductivity Detection

Instrument Type: IC

This work describes the determination of N-Methylpyrrolidine by cation-exchange chromatography with non-suppressed conductivity detection. This method is different from the one described in AN199, which uses suppressed conductivity. The results shown here meet the USP criteria for Organic Impurities, Procedure 1 (Limit of N-Methylpyrrolidine) in the proposed methods for cefepime hydrochloride and Cefepime for Injection.