AN104: Analysis of Personal Care Products by Ion Chromatography

Instrument Type: IC

Ion chromatography (IC) with conductivity detection complements traditional HPLC-UV pharmaceutical separations. IC is especially useful when the analytes do not contain chromophores, or when it is desirable to determine chromophoric and nonchromophoric molecules in a single run. This application note addresses the use of IC for the analysis of personal care products, including compounds found in some toothpastes, hair permanent solutions, and acne medications. Several examples illustrate the variety of separations that can be achieved using IC.

Rapid determination of nicotine salicylate using the Thermo Scientific Acclaim Trinity P1 HPLC column

Instrument Type: HPLC

The Thermo Scientific Acclaim Trinity P1 column was used to separate nicotine and its counterion. The nicotine and salicylate were separated using a phosphate buffer system to permit isocratic elution and UV detection at 210 nm. Alternative wavelengths are 258 nm for nicotine and 296 nm for salicylate.