Quantitative Analysis of Methylmalonic Acid in Plasma Using a Q Exactive Focus High-Resolution Mass Spectrometer for Clinical Research

Instrument Type: LCMSMS

Clinical research laboratories perform analysis of methylmalonic acid (MMA) using LC-MS because of that technique’s sensitivity and selectivity. Usually, the quantitative method is developed on a triple quadrupole mass spectrometer. Here we evaluated a method implemented on a Q Exactive Focus ultra-high resolution quadrupole-Orbitrap mass spectrometer for the best selectivity.