To demonstrate practical approaches that can be used to significantly improve throughput of the ibuprofen USP assay monograph keeping to the spirit o USP-NF Chapter <621> guidelines while maintaining USP quality acceptance criteria. To then take this optimized assay monograph and reduce analysis time even further.

We present the reliable and accurate quantitative analysis of contaminants at the pg/mL level in drinking water using the Thermo Scientific EQuan MAX Plus LC-MS system coupled to the Thermo Scientific TSQ Endura triple quadrupole mass spectrometer. Excellent reproducibility was shown for the target compounds in tap water using 1 mL injections at 0.37× maximum effluent concentration.

Demonstration of the advantages of using the Thermo Scientific Accucore XL C18 4 μm UHPLC column and the Thermo Scientific Vanquish UHPLC system for the separation of ibuprofen, ibuprofen-related compound C, and valerophenone.

In this work the advantages of using the Thermo Scientific Accucore Vanquish C18+ 1.5 μm UHPLC column and the Thermo Scientific Vanquish UHPLC system for the separation of ibuprofen, ibuprofen-related compound C, and valerophenone were demonstrated. The advanced capabilities of the Vanquish UHPLC system allow the Accucore Vanquish UHPLC columns to be operated at higher flow rates that enable development of rapid analytical methods while maintaining performance.

The Thermo Scientific HPLC system is applied for the analysis of ibuprofen and valerophenone. The separation is performed on a Thermo Scientific Accucore C18 column. The method of analysis is based on the USP monograph.