High Resolution LC-MS for Screening and Quantitative Analysis of Antibiotics in Drinking Water Using an Orbitrap and Online Sample Preparation

Instrument Type: LCMS

Most current methodologies for the quantitation of antibiotics in drinking water revolve around analysis using triple stage quadrupole platforms with offline sample preparation. This is a proven technique for the analysis of many contaminants in various types of water samples, but the offline sample preparation steps are time-consuming and prone to operator error and reproducibility problems. We demonstrate the ability to directly inject the water sample without any offline preconcentration. We utilize LC-MS with a Thermo Scientific Exactive Plus Orbitrap MS using HR/AM.