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Separation of ciprofloxacin and ofloxacin using the Chinese Pharmacopeia methodology
Instrument Type: HPLCThe Thermo Scientific Dionex UltiMate 3000 system is applied for the separation of ciprofloxacin and ofloxacin. This was achieved using a Thermo Scientific Acclaim 120 C18 column with UV detection at 278 nm following the method in the Chinese Pharmacopeia. The resolution obtained between ciprofloxacin and ofloxacin was 2.38, which exceeds the specification of greater than 1.5 stated in the pharmacopeia.
An improved separation of Ofloxacin, Ciprofloxacin and impurities using a Thermo Scientific Acclaim 120 C18 HPLC column
Instrument Type: HPLCThe Thermo Scientific Dionex Ultimate 3000 system is applied for the separation of ofloxacin, ciprofloxacin and impurities. This was achieved using a Thermo Scientific Acclaim 120 C18 column with UV detection at 294 nm.