AN348: Extraction of Anthelmintic Drugs from a Veterinary Formulation Using Accelerated Solvent Extraction (ASE)

Instrument Type: Automated Sample Prep

Isolation of the active drug from some veterinary formulations can be difficult because the matrix is often complex. Automated Solvent Extraction (ASE 350) technique is an automated method that uses the smaller amounts of solvents with more efficient extractions at less time than the traditional extraction methods. This application note describes the extraction of the two active species of ivermectin (H2B1a and H2B1b), an anthelmintic drug, from a veterinary formulation containing dried meat products. The drug is prescribed for heartworm treatment in cats and dogs.

Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/L Level Utilizing Online Sample Preparation with LC-MS/MS

Instrument Type: LCMSMS

There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. In response, the U.S. Environmental Protection Agency (EPA) published Method 1694, which determines dozens of PPCPs in water, soil, sediment, and biosolids by HPLC-MS/MS. We demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.