Analysis of Melamine and Cyanuric Acid in Food Matrices by LC-MS/MS

Instrument Type: LCMSMS

In March 2007, several North American manufacturers of pet food voluntarily issued nationwide recall notices for some of their products that were reportedly associated with renal failure in pets. It was discovered that melamine-contaminated China-sourced ingredients had been used to prepare feed for chickens, swine, and catfish. Consequently, the FDA and the USDA have developed methods for the analysis of melamine residues in animal tissue. Both methods use tandem MS detection and employ disposable strong cation exchange SPE cartridges to prepare samples for liquid chromatographic analysis.