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Displaying 1-5 of 9 results for: aggregate

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Chromatographic method for aggregate and fragment analysis of Pertuzumab i.e IgG1 Mab using SEC column.

Instrument Type: HPLC (Biocompatible)

Analysis of protein aggregation and fragment of pertuzumab by size-exclusion chromatography, showing the universal applicability of the Thermo Scientific MAbPac SEC-1 column for aggregate and fragment analysis. Aggregate analysis is major CQA for protein based drugs and requires tight monitoring and control.

Robust, reproducible, and easy-to-implement plasma protein profiling workflow using high-flow UHPLC/MS/MS without depletion

Instrument Type: LCMS

To generate a robust and reproducible bottom-up protein profiling workflow that addresses throughput requirements for plasma biomarker discovery

Chromatographic method for aggregate analysis of Aflibercept i.e fusion protein using SEC column.

Instrument Type: HPLC (Biocompatible)

Analysis of protein aggregation of Aflibercept i.e fusion protein by size-exclusion chromatography, showing the universal applicability of the Thermo Scientific MAbPac SEC-1 column for aggregate analysis of fusion protein. Aggregate analysis is major CQA for protein based drugs and requires tight monitoring and control.

SEC Protein aggregate analysis

Instrument Type: UHPLC

A UHPLC workflow for mAb aggregate analysis that operates continuously for weeks.

A universal chromatography method for aggregate analysis of monocolonal antibodies

Instrument Type: UHPLC

Analysis of protein aggregation of five important biotherapeutic monoclonal antibodies (mAbs) by size-exclusion chromatography, showing the universal applicability of the Thermo Scientific MAbPac SEC-1 column for aggregate analysis of mAbs. The biopharmaceutical industry continues to develop mAb-based biotherapeutics have several key quality attributes that require quantification. This shows the ability to determine quickly and accurately the percentage of aggregates and fragments for five therapeutics as shown with full details in the AN21601 download.