This application note is intended to demonstrate the usability of Vanquish Core instruments for the straightforward application of compendial methods.
Reliable and highly reproducible chromatographic results were obtained when implementing the liquid chromatography-based impurity method from the Ph. Eur. monograph of metolazone.
Simple stability-indicating LC-MS method for erythromycin. Compare the impurity profiles of an erythromycin reference standard with stressed analyte.
To demonstrate how custom injection programs affect chromatographic parameters such as asymmetry, resolution, and efficiency of a selected EP method.
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of the related substances of ganciclovir. The analysis was performed on a Thermo Scientific BioBasic SCX HPLC column using the method described in the EP 9.0 monograph. The results obtained for resolution between the peaks due to ganciclovir and its impurity E met the criteria stated in the EP.
