2,2-bis(4-hydroxyphenyl) propane, commonly known as Bisphenol A (BPA), is one of the primary chemicals used to make plastics. It is also heavily used in the production of various types of food and drink containers. Because BPA has been known to leach from the plastic lining of metal canned food, the potential risks of exposure to BPA have been a great concern over the past few years. We describe a six-minute LC-MS/MS method using automated sample preparation for the assay of BPA in canned infant formula powder by negative ion APCI using a deuterated internal standard (BPA-d16).
