We present a liquid chromatography – high-resolution, accurate-mass (LC-HRAM) methodology using Orbitrap technology as a sensitive, accurate, and reliable quantitative alternative to the use of triple quadrupole mass spectrometers while simultaneously determining unknown perfluorinated compounds in the same drinking water extracts. Based on the EPA method flexibility rule, QA/QC requirements and guidance within EPA Method 537, HRAM Orbitrap technology should be permissible for potential compliance monitoring if PFASs become regulated compounds in US drinking waters.
