An ion chromatography-mass spectrometry (IC-MS) method to meet the analytical need of understanding the sample composition and degradation byproduct in simulated battery electrolytes. Integrating an organic solvent gradient, this method achieves excellent separation of many analytes allowing lithium-ion battery (LIB) manufacturers and researchers to gain knoledge to improve quality assurance, quality control and failure analysis processes to ensure the battery's performance.
The presented 2D-LC-MS system facilitates the straightforward analysis of mAb producing cell culture samples for the upstream monitoring of titer, charge variants, and size variants of the intact antibody. While the first dimension purifies the mAb from matrix components by Protein A affinity chromatography, selectable second dimension mechanisms enable the assessment of the aggregation level by SEC or the abundance monitoring of glycoforms and other variants by SCX.
To demonstrate a targeted LC-UV-SQMS-based peptide monitoring workflow for QC labs, enabling increased productivity in sample preparation, data analysis, and reporting.
Peanuts contain the digestible carbohydrates sucrose, fructose, and glucose, but they also often include non-digestible raffinose, stachyose, and verbascose in varying quantities that pass through the human digestive tract unchanged and are subject to fermentation in the lower gut. For determinations of carbohydrates in food, a method for carbohydrates in peanuts and peanut butters with minimal sample preparation and without requiring pre- or post-column analyte derivatization. The method uses high-performance anion-exchange chromatography with pulsed amperometry detection (HPAE-PAD).
Per- and polyfluoroalkyl substances (PFAS) is the collective name for synthetic fluorinated compounds. Here we describe our lab's results from the EPA draft Method 1621 multi-lab study results to screen for PFAS using adsorbable organic fluorine by combustion ion chromatography. The recovery of 4 types of PFAS from wastewater samplers are discussed. This method was found to be robust, precise, and accurate. Additionally, a technical note is included to describe tips and tricks for successful implementation of EPA Method 1621.
