This application note demonstrates a USP-aligned ion chromatography method for quantitative assay of magnesium sulfate using the Dionex IonPac CS16 column and NGES-C electrolytic suppressor. The method uses suppressed conductivity detection with 48 mM MSA and meets USP system suitability criteria, including Mg/Ca resolution, tailing factor, and %RSD. Linearity was confirmed from 10–300 µg/mL, and sample assays fell within 98–102% with low RSDs. The NGES-C improves baseline stability, noise reduction, and robustness for routine pharmaceutical QC.
This application note presents an ion chromatography method for trace nitrite and nitrate analysis in lactose monohydrate and colloidal silicon dioxide. Using a Dionex IonPac AS19-4µm column and NGES-A suppressor, the method achieved sensitive, selective separation with LOQs of 0.1 µg/g nitrite and 0.2 µg/g nitrate. Strong linearity, precision, and recovery support its use in USP-aligned nitrosamine risk assessment for pharmaceutical excipients
A streamlined TOF workflow using the Cindion C-IC system was developed for PFAS screening in cosmetic products. The method has a TF detection limit of approximately 0.91 ppm, well below the level of 100 ppm often used as a screening threshold for high-fluorine samples, and the method is highly accurate and precise for both TF and TIF determination.
This is additional data not reported in AN268. Shows the effect of a Dionex IonPac CTC-1 trap column trapping interfering dissolved iron from manually prepared MSA eluent. This trap can be used in other applications where acidic eluents might have dissolved metal contamination.
The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ TSQ Quantis™ Plus mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
