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Organic impurities analysis of Cefotaxime using a C18 HPLC column following USP 39 monograph (procedure 2)
Description
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the organic impurities (procedure 2) analysis of Cefotaxime Sodium. The analysis was performed on a Thermo Scientific Syncronis C18 HPLC column using the method described in the USP 39. The results obtained for resolution and tailing factor met the criteria stated in the USP. The results obtained for resolution between the peaks due to Cefotaxime and Cefotaxime related compound E was 13.6(USP criteria of minimum 4.0) and tailing factor for cefotaxime (10 µg/mL) was 1.0 (USP criteria of maximum 2).| Market: | Pharma |
| Keywords: | Cefotaxime, HPLC, UV detection, Syncronis C18, USP 39 monograph, beta-lactam antibiotic |
| Matrix: | N/A |
| Author: | Krishnarao Dara |
| Affiliation: | APAC CoE Lab, Ahmedabad, India |
For Research Use Only. Not for use in diagnostic procedures.
