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Fast pH gradient separation of cetuximab charge variants Be the first to rate this application


The Thermo Scientific Ultimate 3000 BioRS Dual system is used in combination with the Thermo Scientific MabPac SCX-10 RS 2.1x50mm to run fast pH-gradient ion exchange of cetuximab. The pH gradient is generated by using the CX-1 pH-gradient buffers.A fast generic screening method is run with a 10 minutes gradient from pH 5,6 to pH 10,2. The generic screening method isoptimized to achieve high throughput, high resolution separation of the charge variants.
Market: Biopharma
Keywords: BioRS, Biotherapeutics, Erbitux, ion exchange, MAbPac
Matrix: Aqueous solution
Uploaded on 2/10/2015.

For Research Use Only. Not for use in diagnostic procedures.