AN630: EPA Method 557 – Analysis of Haloacetic Acids, Dalapon, and Bromate in Drinking Water by IC-MS/MS: HAA9

Instrument Type: ICMS

Haloacetic acids (HAAs) are formed as disinfection byproducts when municipal chlorination processes react with naturally occurring brominated and chlorinated species. Five HAAs are currently regulated, whereas four others may be included in future regulations. Here we demonstrate the determinations of 0.02 to 0.1 ng/L (ppt) HAA9 concentrations using ion chromatography separations combined with tandem MS on a triple quadrupole mass spectrometry.

AN1076 : Determination of Monochloroacetic Acid in Carbocisteine.

Instrument Type: IC

Carbocisteine is a mucolytic drug that can interact with the bronchial epithelium to improve the breathing of patients with chronic bronchitis and bronchial asthma. The substrate MCAA, which is cardio- and hematotoxic, is inevitably present in the carbocisteine product. Therefore, the determination of MCAA is important for the quality control of carbocisteine production. The commonly used methods to determine MCAA are gas chromatography (GC) and IC. Compared to the GC method that requires precolumn derivatization, the IC method is sensitive and simple, requiring only a direct injection.