AN108:Determination of Transition Metals in Serum and Whole Blood by Ion Chromatography

Instrument Type: IC

The determination of transition metals in physiological fluids is of considerable interest in clinical chemistry. This application note describes an attractive alternative to traditional spectroscopic methods by using the principles of ion exchange. Separation between individual metals can be enhanced or altered simply by changing eluents (pyridine-2, 6-dicarboxylic acid or oxalic acid). This figure illustrates the selectivity on an IonPac CS5A column when using a pyridine-2, 6-dicarboxylic acid eluent.