AN233: Determination of Galactosamine Containing Organic Impurities in Heparin by HPAE-PAD

Instrument Type: IC

In this application note, the organic impurities in heparin are determined by the HPAE-PAD method using the CarboPac PA20 column following the USP monograph method. This method was repeated using manually prepared eluents and an electrolytically generated eluent, with both eluent preparation options providing data that exceeds the system suitability requirements in the monograph.