This application shows a method for HPLC-CAD analysis of sorbitan monooleate, also known as Span 80. Sorbitan esters (also known as Spans) are nonionic surfactants that are derived from sorbitan – the precursor also used to produce polysorbates. Spans are used as emulsifying agents in the preparation of emulsions, creams, and ointments for pharmaceutical and cosmetic use. Spans are used as emulsifiers and stabilizers in food products. In the US Span 60 and 80 are approved for use as food additives while in the EU Span 20, 40, 60, 65, and 80 are approved. Span is also an oil dispersant.
