Cyclodextrins (CDs) have been used as complexing agents to increase water solubility of poorly soluble drugs and to increase their bioavailability.. The presence of oxidizable hydroxyl groups makes CDs well suited for determination by HPAE-PAD. Here, we used Thermo Scientific Dionex CarboPac PA200 Column to evaluate the “Limit of β-CD" according to the USP Monograph. Key performance parameters were evaluated and compared including system suitability, linearity, limits of detection, and precision. The application of the Dionex CarboPac PA200 column to separating other CDs was also examined.
