Thermo Scientific AppsLab Library: Determination of nitrite and nitrate from lactose by ion chromatography using the NGES-A suppressor

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nitrite nitrate analysis from lactose using ic

Description

This application note presents an ion chromatography method for trace nitrite and nitrate analysis in lactose monohydrate and colloidal silicon dioxide. Using a Dionex IonPac AS19-4µm column and NGES-A suppressor, the method achieved sensitive, selective separation with LOQs of 0.1 µg/g nitrite and 0.2 µg/g nitrate. Strong linearity, precision, and recovery support its use in USP-aligned nitrosamine risk assessment for pharmaceutical excipients

Market:	Pharma; BioPharma
Keywords:	Excipients, Pharmaceuticals, USP, IonPac AS19 column, NGES, suppressor
Matrix:	Colloidal Silicon Dioxide, Lactose
Author:	Chanakya Thaker; Neil Rumachik
Affiliation:	Thermo Fisher Scientific

Uploaded on 5/27/2026.

For Research Use Only. Not for use in diagnostic procedures.