Thermo Scientific AppsLab Library: Increased sensitivity for low-input label-free proteomics using the Orbitrap Astral MS and μPAC Neo Plus columns

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increased sensitivity for lowinput labelfree proteomics using orbitrap astral ms μpac neo plus columns

Description

Goal: To demonstrate peptide and protein identification and measurement precision at low sample input levels using data-independent acquisition (DIA) on the Thermo Scientific™ Orbitrap™ Astral™ Mass Spectrometer with the Thermo Scientific™ Vanquish™ Neo UHPLC System and Thermo Scientific™ μPAC™ Neo Plus 50 cm Analytical Column in direct injection and trap-and-elute workflows.

Market:	Proteomics
Keywords:	Vanquish Neo UHPLC, data-independent acquisition, Spectronaut software, Orbitrap Astral Mass Spectrometer, FAIMS Pro Duo Interface, label-free DIA, micro-pillar array columns, μPAC Neo Plus HPLC Columns
Matrix:	cell lysate
Author:	Martinš Jansons
Affiliation:	Thermo Fisher Scientific, CMD

Uploaded on 5/22/2026.

For Research Use Only. Not for use in diagnostic procedures.