Thermo Scientific AppsLab Library: Quantitation of an oral fluid drug panel including THC using the Stellar mass spectrometer

Rate

Ask the Expert

Suggest an Application

Find methods for your needs

Quantitation of an oral fluid drug panel including THC using the Stellar mass spectrometer Be the first to rate this application

Combined Extracted Ion Chromatogram

Stellar MS

Extraction Protocol

‹ ›

Description

The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ Stellar™ mass spectrometer is used for the separation and detection of drugs of abuse in oral fluid matrix. The SPE extraction uses XTR tips with mixed mode SCX/WAX chemistry. Using a Thermo Scientific™ Accucore™ Biphenyl column with a total run time of 4.5 minutes, all isomers were separated, including methamphetamine / phentermine and hydromorphone / morphine. The method includes both CID (resonance-type, unique to ion traps) and HCD (beam-type) activations for more optimized fragmentation.

Market:	Clinical Research
Keywords:	drugs of abuse, Toxicology, clinical, Forensics, Oral Fluid
Matrix:	oral fluid

Uploaded on 3/6/2026.

For Research Use Only. Not for use in diagnostic procedures.