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A reliable method using a UHPLC/UV/CAD/MS multidetector platform for routine quantification and library matching of extractable compounds from PVC tubing and wound dressings
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Description
The Thermo Scientific™ Vanquish™ Duo for Inverse Gradient is used for a multidetector analysis of extractables from plastic food contact and pharmaceutical products. A Thermo Scientific Hypersil GOLD 1.9 µm column was used with charged aerosol, MS and UV detection at 230 nm. The 35 minute method allows quantification of unknown nonvolatile contaminants and clearly classifies unknowns as semivolatiles or nonvolatiles. The inverse gradient is implemented without baseline drift or detrimental impact on MS LOQs and a capillary mixer improves quantification accuracy.| Market: | Pharma |
| Keywords: | Charged aerosol detector, CAD, single quadrupole mass spectrometry, Vanquish Duo UHPLC System, compound identification, epoxidized soybean oil |
| Matrix: | 30/70 water/methanol |
| Author: | Katherine Lovejoy ,‡ Xiaochun Yu,# Carolin Kraus,‡ Basant Soliman‡ |
| Affiliation: | ‡Thermo Fisher Scientific, HPLC Factory Site, Germering, Germany #PPD® Laboratories, GMP Labs, a part of Thermo Fisher Scientific, Middleton, Wisconsin, USA |
