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Parallel analysis of drug product for assay and related substances determination Be the first to rate this application


This application note describes a comprehensive analysis of a drug substance, running the same chromatographic method but requiring different run times and target analyte concentrations for the analysis of an assay and impurity determination of metformin hydrochloride in tablets. With conventional (U)HPLC systems, this would either require two different systems or sequential analysis.
Market: Pharma
Keywords: HPLC, Related substances, Impurity, UHPLC, Assay, productivity, Vanquish Duo for Dual LC, throughput, 1-cyanoguanidine, Metformin hydrochloride
Matrix: Acetonitrile, phosphate buffer, Water
Author: Deepak Nikam*, Bhushan Pandit**, Sylvia Grosse***
Affiliation: *Harman Finochem Ltd, Mumbai, India; **Thermo Fisher Scientific, Mumbai, India; ***Thermo Fisher Scientific, Germering, Germany
Uploaded on 9/2/2022.

For Research Use Only. Not for use in diagnostic procedures.