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Parallel analysis of drug product for assay and related substances determination
Description
This application note describes a comprehensive analysis of a drug substance, running the same chromatographic method but requiring different run times and target analyte concentrations for the analysis of an assay and impurity determination of metformin hydrochloride in tablets. With conventional (U)HPLC systems, this would either require two different systems or sequential analysis.Market: | Pharma |
Keywords: | HPLC, Related substances, Impurity, UHPLC, Assay, productivity, Vanquish Duo for Dual LC, throughput, 1-cyanoguanidine, Metformin hydrochloride |
Matrix: | Acetonitrile, phosphate buffer, Water |
Author: | Deepak Nikam*, Bhushan Pandit**, Sylvia Grosse*** |
Affiliation: | *Harman Finochem Ltd, Mumbai, India; **Thermo Fisher Scientific, Mumbai, India; ***Thermo Fisher Scientific, Germering, Germany |
For Research Use Only. Not for use in diagnostic procedures.