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AN000170: A Fast HPAE-PAD Method for Determination of Carbohydrates and Glycols in Pharmaceutical Formulations Be the first to rate this application


This application note describes a convenient, fast, and sensitive method that uses a Thermo Scientific™ Dionex™ CarboPac™ PA300 column and electrolytic eluent generation. The Dionex CarboPac PA300-4μm column is packed with a new 4 μm particle size supermacroporous resin to achieve high efficiency and high-resolution separations. Using this column, a 16.8 min method that resolved six analytes, including glycol and other carbohydrates, was designed. Results for method linearity, robustness, and accuracy for glycol and carbohydrate quantification in OTC samples are discussed here.
Market: Pharma
Keywords: High-performance anion-exchange chromatography, HPAE-PAD, Dionex Integrion HPIC, TN 20, TN 70671, TN20, TN70671, Dionex CarboPac PA300 column, FODMAP, inactive ingredient, AN 000170
Matrix: DI water
Author: Sachin Patil and Jeffrey Rohrer
Affiliation: Thermo Fisher Scientific, Sunnyvale, CA, USA
Uploaded on 9/23/2021.