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AN000170: A Fast HPAE-PAD Method for Determination of Carbohydrates and Glycols in Pharmaceutical Formulations
Description
This application note describes a convenient, fast, and sensitive method that uses a Thermo Scientific™ Dionex™ CarboPac™ PA300 column and electrolytic eluent generation. The Dionex CarboPac PA300-4μm column is packed with a new 4 μm particle size supermacroporous resin to achieve high efficiency and high-resolution separations. Using this column, a 16.8 min method that resolved six analytes, including glycol and other carbohydrates, was designed. Results for method linearity, robustness, and accuracy for glycol and carbohydrate quantification in OTC samples are discussed here.| Market: | Pharma |
| Keywords: | High-performance anion-exchange chromatography, HPAE-PAD, Dionex Integrion HPIC, TN 20, TN 70671, TN20, TN70671, Dionex CarboPac PA300 column, FODMAP, inactive ingredient, AN 000170 |
| Matrix: | DI water |
| Author: | Sachin Patil and Jeffrey Rohrer |
| Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA, USA |
