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AN74041: Magnesium Oxide Monograph Modernization with Ion Chromatography
Description
In this work, we evaluated the IC method in the proposed USP monograph for the MgO assay and Limit of Calcium test. Magnesium and calcium ions were separated on a Dionex IonPac CS16 column set followed by suppressed conductivity detection. Key performance parameters were evaluated, including separation, system suitability, linearity, limit of detection, and precision. MgO tablets and capsules were analyzed and evaluated in accordance with the proposed USP monographs. The percentage of MgO and the limit of calcium results were compared with the proposed USP monographs’ acceptance criteria.Market: | Pharma |
Keywords: | Magnesium, USP monograph, Drug Product, USP-NF, calcium carbonate, Dionex ICS 6000 system, Dionex IonPac CS16 column, MgO tablets, Magnesium oxide, MgO capsules, MgO supplements, AN 74041 |
Matrix: | Magnesium oxide tablets and capsules |
Author: | Manali Aggrawal; Jeff Rohrer |
Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA USA |
For Research Use Only. Not for use in diagnostic procedures.