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Polysorbate 80 profiling by HPLC with mass and charged aerosol detection
Description
An HPLC-based approach to monitor the characteristics of polysorbate 80 samples that provides operational simplicity while generating a high degree of information is proposed. The reversed-phase method is highly optimized to ensure sufficient separation of different compound classes within a reasonable run time to permit the fingerprinting of polysorbate 80 samples and detect variability between different suppliers, grades, and production batches.| Market: | BioPharma; Pharma; Food and Beverage |
| Keywords: | Surfactants, Charged aerosol detection, Polysorbate, Tween, CAD, Formulations, Vanquish Flex, inverse gradient, excipient, ISQ EM, mass detection, single quadrupole, ultra high performance liquid |
| Matrix: | Water |
| Author: | Mauro De Pra, Denis A. Ispan, Katherine Lovejoy, Sylvia Grosse, Stephan Meding, Frank Steiner |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
