Polysorbate 80 profiling by HPLC with mass and charged aerosol detection
DescriptionAn HPLC-based approach to monitor the characteristics of polysorbate 80 samples that provides operational simplicity while generating a high degree of information is proposed. The reversed-phase method is highly optimized to ensure sufficient separation of different compound classes within a reasonable run time to permit the fingerprinting of polysorbate 80 samples and detect variability between different suppliers, grades, and production batches.
|Market:||BioPharma; Pharma; Food and Beverage|
|Keywords:||Surfactants, Charged aerosol detection, Polysorbate, Tween, CAD, Formulations, Vanquish Flex, inverse gradient, excipient, ISQ EM, mass detection, single quadrupole, ultra high performance liquid|
|Author:||Mauro De Pra, Denis A. Ispan, Katherine Lovejoy, Sylvia Grosse, Stephan Meding, Frank Steiner|
|Affiliation:||Thermo Fisher Scientific|
For Research Use Only. Not for use in diagnostic procedures.