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Polysorbate 80 profiling by HPLC with mass and charged aerosol detection Be the first to rate this application


An HPLC-based approach to monitor the characteristics of polysorbate 80 samples that provides operational simplicity while generating a high degree of information is proposed. The reversed-phase method is highly optimized to ensure sufficient separation of different compound classes within a reasonable run time to permit the fingerprinting of polysorbate 80 samples and detect variability between different suppliers, grades, and production batches.
Market: BioPharma; Pharma; Food and Beverage
Keywords: Surfactants, Charged aerosol detection, Polysorbate, Tween, CAD, Formulations, Vanquish Flex, inverse gradient, excipient, ISQ EM, mass detection, single quadrupole, ultra high performance liquid
Matrix: Water
Author: Mauro De Pra, Denis A. Ispan, Katherine Lovejoy, Sylvia Grosse, Stephan Meding, Frank Steiner
Affiliation: Thermo Fisher Scientific
Uploaded on 3/8/2021.

For Research Use Only. Not for use in diagnostic procedures.