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AN73749: Determination of Methanesulfonic Acid in Busulfan by Ion Chromatography
Description
We evaluated the proposed USP Busulfan monograph method for the “Limit of Methanesulfonic Acid”. MSA was separated on a Dionex IonPac AS11-HC column set followed by suppressed conductivity detection. The method was further evaluated with a slight modification to the sample preparation method. The busulfan sample was prepared in cold 30:70 acetonitrile:water (30% MeCN) instead of water. We also set the autosampler temperature set to 8 °C instead of 25 °C. Key performance parameters were evaluated including separation, system suitability, linearity, limit of detection, and precision.| Market: | Pharma |
| Keywords: | Dionex ICS-5000+ System, USP monograph, methanesulfonic acid, Dionex ICS-6000 system, Dionex IonPac AS11-HC column, MSA, USP-PF, AN 73749 |
| Matrix: | Busulfan |
| Author: | Manali Aggrawal; Jeff Rohrer |
| Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA USA |
