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AN73482: Determination of Ammonia Impurity in Potassium Bitartrate using Ion Chromatography
Description
We developed a sensitive and robust ion chromatography (IC)-based test for the determination of ammonia impurity in potassium bitartrate to modernize the test in the United States Pharmacopeia’s (USP) Potassium Bitartrate monograph. Our IC method offers a significant improvement to the current impurity test in the USP monograph. The 5 min method uses a Thermo Scientific™ Dionex™ IonPac™ CS16 high capacity column, an electrolytically generated methanesulfonic acid (MSA) eluent, and suppressed conductivity detection on a Reagent-Free™ Ion Chromatography (RFIC™) system.| Market: | Pharma |
| Keywords: | Pharmaceutical, USP monograph, Dionex IonPac CS16 Column, suppressed conductivity detection, RFIC System, drug substance, AN 73482 |
| Matrix: | DI water |
| Author: | Beibei Huang and Jeffrey Rohrer |
| Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA USA |
