Find methods for your needs

AN73482: Determination of Ammonia Impurity in Potassium Bitartrate using Ion Chromatography Be the first to rate this application

Description

We developed a sensitive and robust ion chromatography (IC)-based test for the determination of ammonia impurity in potassium bitartrate to modernize the test in the United States Pharmacopeia’s (USP) Potassium Bitartrate monograph. Our IC method offers a significant improvement to the current impurity test in the USP monograph. The 5 min method uses a Thermo Scientific™ Dionex™ IonPac™ CS16 high capacity column, an electrolytically generated methanesulfonic acid (MSA) eluent, and suppressed conductivity detection on a Reagent-Free™ Ion Chromatography (RFIC™) system.
Market: Pharma
Keywords: Pharmaceutical, USP monograph, Dionex IonPac CS16 Column, suppressed conductivity detection, RFIC System, drug substance, AN 73482
Matrix: DI water
Author: Beibei Huang and Jeffrey Rohrer
Affiliation: Thermo Fisher Scientific, Sunnyvale, CA USA
Uploaded on 4/23/2020.