Rate
Ask the Expert
Suggest an Application
Add to Favorites
Download eWorkflow
CreateParts List
Tell a Friend
PrintFind methods for your needs
AN73344: IC-MS for the Determination of Organic Acids in Pharmaceutical Solutions
Description
This application note illustrates the use of an easy-to-implement IC-MS method for the determination of aliphatic and unsaturated organic acids in pharmaceutical solutions. This workflow employs both suppressed conductivity and MS detection to increase the information available from each sample. Samples were separated on a high-resolution Dionex™ IonPac™ AS11-HC-4μm column set using a Dionex™ Integrion™ HPIC™ system with suppressed conductivity detection. The sequential MS detection was achieved using a Thermo Scientific™ ISQ™ EC single quadrupole mass spectrometer.| Market: | Pharma |
| Keywords: | Formic acid, Pentanoic acid, RFIC, ion chromatography, IC, ISQ EC single quadrupole mass spectrometer, aliphatic and unsaturated, Dionex IonPac AS11-HC-4μm, suppression, AN 73344, butanoic acid, crotonic acid, propinoic acid, 2-butynoic acid, 2-pentynoic acid, 2-propioloc aicd |
| Matrix: | 2-butynoic acid (pharmaceutical solution) |
| Author: | Detlef Jensen (1); Wai-Chi Man (2) |
| Affiliation: | 1. Thermo Scientific GmbH, Dreieich, Germany; 2. Thermo Scientific, Hemel Hempstead, UK |
For Research Use Only. Not for use in diagnostic procedures.
