AB72910: Fast and Sensitive Analysis of N-Containing Bisphosphonates without Derivatization using IC-MS
DescriptionDue to the very polar and strong chelating characteristics of bisphosphonates, their analysis represents a real analytical challenge. Here separation of N-containing bisphosphonates and three other bisphosphonates was achieved without derivatization. After an anion-exchange separation, the analytes were passed through an anion suppressor before detection by suppressed conductivity and single quadrupole mass spectrometry in Selected Ion Monitoring mode without the aid of a desolvation agent at any step of separation or electrospray ionization.
|Keywords:||Clodronate, Dionex AERS 500 Suppressor, Etidronate, risedronate, Tiludronate, HPIC, RFIC, IC-MS, Drug Product, Single quadrupole mass spectrometer, ISQ EC mass spectrometer, ICS-6000, TN72611, AB 72910, alendronate, AN 1001, AN1001, Dionex IonPac AS18 4μm Fast Column, pamidronate, pharmaceutical compounds, zoledronate, AB72910|
|Matrix:||Pharmaceutical in water|
|Author:||Sylvain Morel, Xavier Deruy|
|Affiliation:||Thermo Fisher Scientific|
For Research Use Only. Not for use in diagnostic procedures.