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AB72910: Fast and Sensitive Analysis of N-Containing Bisphosphonates without Derivatization using IC-MS Be the first to rate this application

ncontaining bisphosphonates determination


Due to the very polar and strong chelating characteristics of bisphosphonates, their analysis represents a real analytical challenge. Here separation of N-containing bisphosphonates and three other bisphosphonates was achieved without derivatization. After an anion-exchange separation, the analytes were passed through an anion suppressor before detection by suppressed conductivity and single quadrupole mass spectrometry in Selected Ion Monitoring mode without the aid of a desolvation agent at any step of separation or electrospray ionization.
Market: Pharma
Keywords: Clodronate, Dionex AERS 500 Suppressor, Etidronate, risedronate, Tiludronate, HPIC, RFIC, IC-MS, Drug Product, Single quadrupole mass spectrometer, ISQ EC mass spectrometer, ICS-6000, TN72611, AB 72910, alendronate, AN 1001, AN1001, Dionex IonPac AS18 4μm Fast Column, pamidronate, pharmaceutical compounds, zoledronate, AB72910
Matrix: Pharmaceutical in water
Author: Sylvain Morel, Xavier Deruy
Affiliation: Thermo Fisher Scientific
Uploaded on 1/14/2019.

For Research Use Only. Not for use in diagnostic procedures.