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AN72880: Determination of Spectinomycin and Related Impurities in Spectinomycin Dihydrochloride
Description
This application note demonstrates that spectinomycin dihydrochloride and related impurities can be separated with a Dionex IonPac AmG-3µm C18 column using a simple eluent method (0.1M TFA) compared to the method in the EP monograph. The separation, repeatability, and sensitivity of this method were found to meet or exceed the current EP Spectinomycin Dihydrochloride monograph performance requirements. This method is reliable and can be used for the routine monitoring of spectinomycin.| Market: | Pharma |
| Keywords: | aminoglycoside, Antibiotic, Drug Substance, Electrochemical detection, PAD, Dionex IonPac AmG-3µm C18 column, EP, ion-pair reversed-phase HPLC, Dionex ICS-5000+ HPIC system, Dionex ICS-6000 HPIC system |
| Matrix: | Water |
| Author: | Jingli Hu and Jeffrey Rohrer |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
