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Rapid quantitation of therapeutic antibodies in animal plasma
Description
To demonstrate the rapid quantitation of a low-level human IgG in animal plasma by LC/MS/MS using the Thermo Scientific™ SMART Digest™ Immunoaffinity (IA) kits (including magnetic and non-magnetic versions of the Streptavidin kit, Protein A kit, and Protein G kit), which combine the IA capture and digestion process into a single well. The assay is required to be both selective and accurate.| Market: | BioPharma |
| Keywords: | Human IgG, Biopharmaceutical, SRM, UHPLC, IgG, Quantitation, MRM, Protein A, Sample preparation, Biotherapeutic, 96 well plates, Accucore™ C18, affinity proteomics, bioanalysis, biotin, immunoaffinity, immunocapture, monoclonal antibody (mAb), peptide analysis, protein digestion, protein enzyme digestion, Protein G, protein magnetic beads, SMART Digest™ Immunoaffinity (IA) Kits, Streptavidin |
| Matrix: | Rat plasma |
| Author: | Xin Zhang1 , John O’Grady2 , Kevin Meyer2 |
| Affiliation: | 1. Thermo Fisher Scientific, Sunnyvale, CA, USA 2. Perfinity Biosciences Inc., West Lafayette, IN, USA |
For Research Use Only. Not for use in diagnostic procedures.
