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Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate
DescriptionTo demonstrate the effectiveness of a simple pH gradient/ion-exchange chromatography workflow approach to the characterization of charge variant profiles of an innovator molecule (cetuximab) and a candidate biosimilar. To show the assay is simple, reproducible, easily optimized and resolves variants effectively.
|Keywords:||Monoclonal antibody, protein characterization, Biopharmaceutical, IgG, mAb, cation exchange chromatography, Cetuximab, Innovator, Biosimilar, pH gradient buffer, charge variant analysis, NIBRT, Critical quality attribute, QA/QC, Biotherapeutic, CX-1 pH buffer, CEX, intact protein analysis, ion-exchange chromatography|
For Research Use Only. Not for use in diagnostic procedures.