Thermo Scientific AppsLab Library: Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate

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Description

To demonstrate the effectiveness of a simple pH gradient/ion-exchange chromatography workflow approach to the characterization of charge variant profiles of an innovator molecule (cetuximab) and a candidate biosimilar. To show the assay is simple, reproducible, easily optimized and resolves variants effectively.

Market:	BioPharma
Keywords:	Monoclonal antibody, protein characterization, Biopharmaceutical, IgG, mAb, cation exchange chromatography, Cetuximab, Innovator, Biosimilar, pH gradient buffer, charge variant analysis, NIBRT, Critical quality attribute, QA/QC, Biotherapeutic, CX-1 pH buffer, CEX, intact protein analysis, ion-exchange chromatography
Matrix:	Water
Author:	NIBRT

Uploaded on 7/4/2018.

For Research Use Only. Not for use in diagnostic procedures.