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Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies Be the first to rate this application

phbased gradients for charged variant analysis


To demonstrate the CX-1 pH buffer system is capable of charge variant determination for the majority of therapeutic monoclonal antibody species. To show the ease of optimization and improved reproducibility of this buffer system when compared to salt-based gradient systems used for charge variant analysis.
Market: BioPharma
Keywords: Monoclonal antibody, Biopharmaceutical, UHPLC, IgG, mAb, Bevacizumab, Infliximab, Cetuximab, Trastuzumab, Biosimilar, MabPac SCX-10, pH gradient buffer, charge variant analysis, Vanquish Flex, NIBRT, Critical quality attribute, QA/QC, Biotherapeutic, CX-1 pH buffer, ion exchange chromatography, ntact protein analysis
Matrix: Formulation Buffer, Water
Author: NIBRT
Uploaded on 7/4/2018.

For Research Use Only. Not for use in diagnostic procedures.