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Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies
![phbased gradients for charged variant analysis](/Image/AppImage/4159/20180813064414/phbased-gradients-for-charged-variant-analysis?imageNameOnDisk=BioPharma.jpg)
Description
To demonstrate the CX-1 pH buffer system is capable of charge variant determination for the majority of therapeutic monoclonal antibody species. To show the ease of optimization and improved reproducibility of this buffer system when compared to salt-based gradient systems used for charge variant analysis.Market: | BioPharma |
Keywords: | Monoclonal antibody, Biopharmaceutical, UHPLC, IgG, mAb, Bevacizumab, Infliximab, Cetuximab, Trastuzumab, Biosimilar, MabPac SCX-10, pH gradient buffer, charge variant analysis, Vanquish Flex, NIBRT, Critical quality attribute, QA/QC, Biotherapeutic, CX-1 pH buffer, ion exchange chromatography, ntact protein analysis |
Matrix: | Formulation Buffer, Water |
Author: | NIBRT |
For Research Use Only. Not for use in diagnostic procedures.