Thermo Scientific AppsLab Library: Analysis of pharmaceutical products for their elemental impurities with the Thermo Scientific iCAP RQ ICP-MS

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Recoveries (in %) for the 0.5J spike level

Recoveries (in %) for the 1.5J spike level

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Description

To demonstrate the use of the Thermo Scientific™ iCAP™ RQ ICP-MS to accurately determine concentrations of elemental impurities in pharmaceutical products brought into solution using microwave digestion. All sample preparation, measurement and data evaluation to be compatible with the guidelines defined in USP chapters <232> Elemental Impurities – Limits and <233> Elemental Impurities Procedures.

Market:	Pharma
Keywords:	USP 232, Microwave digestion, United States Pharmacopeia, FDA 21 CFR part 11, Pharmaceutical compliance, Pharmaceutical preparations, USP 233
Matrix:	1.2% HNO3 and 0.5% HCl
Author:	Julian Wills and Daniel Kutscher
Affiliation:	Thermo Fisher Scientific, Bremen, Germany

Uploaded on 5/24/2018.

For Research Use Only. Not for use in diagnostic procedures.